Surgeon General's Workshop on Deep Vein ThrombosisMajor Risk Factors for Venous Thrombosis1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 Major Risk Factors for Venous Thrombosis Mary Cushman, MD
Graphic showing VTE Risk factors:
These RFs all add together to enhance risk and it is most common that more than one of these is present in individuals affected by thrombosis
Abdollahi Thromb Haemost 2003;89:493. Tsai M Arch Intern Med 2002;162:1182.
Abdollahi Thromb Haemost 2003;89:493. Cushman JAMA 2004;292:1573.
SLIDE 5: Obesity Trends* Among U.S. Adults BRFSS, 1991, 1996, 2004 (*BMI ?30, or about 30 lbs overweight for 5’4” person)
The association of obesity with thrombosis is especially important currently in the United States because obesity is increasing dramatically. Between 1991 and 2004 rates of obesity have more than doubled, with estimates as high as 30% in some areas of the United States. To illustrate the impact of this obesity epidemic on expected rates of thrombosis in the United States we used data from the United States Census and the Centers for Disease Control and Prevention to estimate the rates of thrombosis attributed to obesity from 1990 to 2000. We estimate that in 1990 there were 18,500 cases of venous thrombosis among obese people aged 45-64 years (based on the number of people in that age range, a prevalence of obesity of 10% at that time, and the expected rate of thrombosis with obesity compared to normal weight). However, in 2000, we estimate that with a 25% rate of obesity, there were 62,000 cases of thrombosis among obese persons aged 45-64. If the prevalence of obesity had stayed at 10% in 2000, only 24,000 cases of thrombosis would have been expected in obese persons in 2000. Thus, in 2000, there were 38,000 excess thrombosis cases among people aged 45-64 solely due to the rise in obesity. Obesity in the US, age 45-64
Obesity in the US, age 45-64
If only 10% were obese in 2000 we would have 24,000 cases in this age group
SLIDE 9: Air Travel and Thrombosis Precise incidence unclear Risk higher with
SLIDE 10: Genetic VTE Risk Factors
* elevated factor VIII tends to be found in families and is partly related to blood type. The precise genetic disorder causing this is not known. SLIDE 11: World Distribution of FVL Map of the world showing world distribution of FVL SLIDE 12: VTE Risk Factor Model Graphic showing the VTE Risk Factor Model Venous events often occur when multiple risk factors, including genetic and environmental, are present at the same time. SLIDE 13: How Can We Intervene?
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